Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Presynaptic currents in frog motor endings.

A Mallart

    Pflugers Archiv : European Journal of Physiology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals a non-uniform distribution of sodium (Na) and potassium (K) channels in frog nerve endings. Na channels concentrate near the terminal

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dramatic impact of morbid obesity on child lung development.

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2021
    Same author

    [Effects of an educational program in non-adherent apneic patients treated with continuous positive airway pressure].

    Revue de pneumologie clinique·2013
    Same author

    [Idiopathic pulmonary fibrosis and sleep disorders].

    Revue de pneumologie clinique·2013
    Same author

    Competition between motor nerves in the establishment of neuromuscular junctions in striated muscles of Xenopus laevis.

    Neuroscience letters·2009
    Same author

    Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study.

    The European respiratory journal·2009
    Same author

    Physiologic correlates of dyspnea in patients with morbid obesity.

    International journal of obesity (2005)·2006

    Area of Science:

    • Neuroscience
    • Cellular Electrophysiology
    • Ion Channel Physiology

    Background:

    • Presynaptic terminals are crucial for neuronal communication.
    • The distribution of ion channels influences action potential propagation and neurotransmitter release.
    • Previous understanding of channel distribution in non-myelinated nerve endings is limited.

    Purpose of the Study:

    • To investigate the spatial distribution of sodium (Na) and potassium (K) channels in non-myelinated frog nerve endings.
    • To correlate channel distribution with observed membrane current patterns.
    • To elucidate the role of specific ion channels in presynaptic terminal function.

    Main Methods:

    • Recording of membrane currents from non-myelinated frog nerve endings using external electrodes.

    Related Experiment Videos

  • Utilizing specific channel blocking agents to identify Na and K channel contributions.
  • Analyzing signal shapes at varying distances from the myelin end to infer channel density.

    • Main Results:

    • Sodium (Na) channels exhibit a non-uniform distribution, with highest density in the initial half of terminal branches and minimal presence at the extreme end.
    • Potassium (K) channels are more broadly distributed, with higher density in medial regions of the terminal.
    • Suppression of K conductance unmasked an outward calcium (Ca) current near the myelin end.

    Conclusions:

    • The non-uniform distribution of Na and K channels significantly shapes membrane currents in frog presynaptic terminals.
    • This specific channel localization likely optimizes action potential initiation and propagation along the terminal branches.
    • The findings provide critical insights into the electrophysiological specialization of non-myelinated nerve endings.