Effects of catecholamine-related mammalian alkaloids on spontaneous and vasopressin-induced behavior in mice

Heterocyclic catechol derivatives (tetrahydroisoquinoline alkaloids) are known to be formed endogenously via condensation of the catecholamines with carbonyl compounds. In this study, the effects of a variety of representative simple isoquinolines, benzyl isoquinolines, bicyclic isoquinoline-derived alkaloids (pavines and isopavines), an aporphine and berberine were investigated after intracerebroventricular injection in mice. Most (thirteen) of the alkaloids studied were found to induce significant alterations in three behavioral parameters (immobility, grooming and scratching behavior). In addition, the stereotypic scratching behavior elicited by central injection of arginine-vasopressin (AVP) was significantly antagonized by only one of these, 6-O-methyl-tetrahydropapaveroline (6-O-methyl-THP). To a lesser extent, (-)THP and the pavine, (+/-)bisnorargemonine, were also effective. That this rather specific effect did not involve opioid receptors was indicated by the failure of naloxone to reverse the antagonism by 6-O-methyl-THP.