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Localized heat urticaria.

L Daman, P Lieberman, M Ganier

    The Journal of Allergy and Clinical Immunology
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Localized heat urticaria involves complement system activation, not histamine release. Heat challenges reveal alternative pathway involvement and endothelial cell damage in this skin condition.

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    Area of Science:

    • Immunology
    • Dermatology
    • Pathophysiology

    Background:

    • Localized heat urticaria is a rare physical urticaria triggered by heat exposure.
    • Understanding its underlying mechanisms is crucial for effective management.

    Observation:

    • Heat challenge in a patient with localized heat urticaria.
    • Analysis of serum complement components (total hemolytic complement, C3, factor B, C4, C5) and plasma histamine levels.
    • Electron microscopy of affected skin tissue.

    Findings:

    • Serum levels of total hemolytic complement, C3, and factor B significantly decreased post-heat challenge.
    • Levels of C4 and C5 remained unchanged.
    • Plasma histamine levels were unaltered.
    • Electron microscopy showed endothelial cell damage and neutrophilic degranulation, with intact mast cells.

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    Implications:

    • The findings suggest activation of the alternative complement pathway is integral to localized heat urticaria pathogenesis.
    • Mast cell degranulation and subsequent histamine release do not appear to be primary drivers of this condition.
    • Further research into complement inhibition may offer novel therapeutic strategies for localized heat urticaria.