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Dermal alternariasis in a kidney transplant recipient
Dermatologica
|January 1, 1984
Summary
Dermal alternariasis is an emerging infectious disease affecting immunocompromised individuals, particularly kidney transplant recipients. Diagnosis requires specific stains and cultures, with ketoconazole recommended for treatment.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Transplantation Immunology
Background:
- Dermal alternariasis is an emerging fungal infection associated with iatrogenic immunodepression.
- Kidney transplant recipients are particularly susceptible due to long-term immunosuppressive therapy.
Observation:
- Clinical presentation of dermal alternariasis in immunocompromised patients.
- Diagnostic challenges and methodologies for identifying the causative agent.
Findings:
- Diagnosis relies on histopathological examination using Periodic acid-Schiff and Grocott stains.
- Mycological cultures are essential for confirming the presence of the fungus.
- Ketoconazole demonstrates efficacy as a primary treatment modality.
Implications:
- Highlights the importance of recognizing and diagnosing rare fungal infections in transplant populations.
- Emphasizes the need for tailored diagnostic approaches in immunocompromised hosts.
- Suggests ketoconazole as a key therapeutic agent for managing dermal alternariasis.