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Variation in V lambda genes in the genus Mus.

C L Scott, M Potter

    Journal of Immunology (Baltimore, Md. : 1950)
    |May 1, 1984
    PubMed
    Summary
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    Wild mice show significant variation in immunoglobulin lambda (Ig V lambda) genes compared to inbred strains. Gene deletion events may explain the lower Ig V lambda gene counts in some mouse species.

    Area of Science:

    • Immunogenetics
    • Comparative genomics
    • Mammalian evolution

    Background:

    • The immunoglobulin lambda (Ig V lambda) gene repertoire is crucial for adaptive immunity.
    • Inbred mouse strains, like BALB/c, possess a defined set of Ig V lambda genes.
    • Understanding gene copy number variation in wild mouse populations provides insights into evolutionary processes.

    Purpose of the Study:

    • To investigate the diversity and copy number of Ig V lambda genes across different species and subgenera of the genus Mus.
    • To compare the Ig V lambda gene repertoire of feral mice with that of the inbred BALB/c strain.
    • To explore potential mechanisms driving Ig V lambda gene evolution, such as gene duplication and deletion.

    Main Methods:

    • Comparative analysis of Ig V lambda gene complements.

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  • Examination of nine feral mouse species representing four subgenera of the genus Mus.
  • Comparison with Ig V lambda gene data from BALB/c inbred mice.

    • Main Results:

    • Feral mice exhibit variation in Ig V lambda gene copy number, unlike the consistent two genes in inbred strains.
    • M. musculus domesticus and other M. musculus subspecies possess at least three V lambda genes, suggesting loss during inbreeding.
    • More distantly related species (M. cookii, M. platythrix) have a higher number (4-6) and greater heterogeneity of V lambda genes.

    Conclusions:

    • Evidence suggests a gene reiteration mechanism involving duplication of V lambda and C lambda gene units.
    • The lower V lambda gene counts in M. musculus, M. spicelegus, and M. spretus may result from deletion events post-divergence.
    • Ancestral Mus species likely possessed a larger V lambda gene repertoire than observed in modern species.