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[Cefotiam passage into the maxillary sinus tissues].

M Nakashima, H Ikoma, M Yokoyama

    The Japanese Journal of Antibiotics
    |October 1, 1983
    PubMed
    Summary

    This study measured cefotiam (CTM) tissue concentrations and antibacterial activity in chronic sinusitis patients. CTM showed significant concentrations in maxillary sinus mucosa and effective activity against common bacteria found in sinus infections.

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    Area of Science:

    • Pharmacology
    • Microbiology
    • Clinical Medicine

    Context:

    • Chronic sinusitis and maxillary cysts are common conditions often requiring antibiotic treatment.
    • Understanding antibiotic distribution and efficacy within affected tissues is crucial for effective therapy.
    • Cefotiam (CTM) is a cephalosporin antibiotic with a broad spectrum of activity.

    Purpose:

    • To determine the tissue concentrations of cefotiam (CTM) in patients with chronic sinusitis and maxillary cysts.
    • To evaluate the in vitro antibacterial activity of CTM against pathogens isolated from maxillary sinus pus.

    Summary:

    • Following a 1g intravenous injection of CTM, concentrations of 16.53 µg/g and 13.26 µg/g were observed in the maxillary sinus mucosa and maxillary cyst tissues, respectively, one hour post-administration.

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  • CTM demonstrated antibacterial activity against key pathogens including Escherichia coli, Staphylococcus epidermidis, Aerococcus, Acidaminococcus fermentans, and Peptostreptococcus anaerobius, with the highest Minimum Inhibitory Concentration (MIC) recorded at 3.13 µg/ml.
  • These findings indicate favorable tissue penetration and antimicrobial efficacy of CTM relevant to treating maxillary sinus infections.

    • Impact:

    • Provides essential pharmacokinetic data on CTM in relevant head and neck tissues.
    • Supports the potential clinical utility of CTM for treating bacterial infections of the maxillary sinus.
    • Contributes to evidence-based antibiotic selection for sinonasal infections.