Effects of beta-receptor blockers in pharmacology EEG

10 normal volunteers (5 females, 5 males, 18-30 years) were treated for 4 days with the beta-blocker sotalol, 320 or 960 mg/day, 5 persons each in random order. A placebo was applied 5 days before and 2 days afterwards. Changes in blood pressure and pulse were not pronounced. EEG data from vigilance-controlled EEGs, evaluated in a spectral parameter analysis, showed a significant decrease of the absolute and relative alpha-power and the dominant alpha-amplitude and so far indicate a central nervous system action of sotalol.