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Isolation of Lymphocytes from Mouse Genital Tract Mucosa

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Persistent diffuse lymphadenopathy in homosexual men: endpoint or prodrome?

D I Abrams, B J Lewis, J H Beckstead

Annals of Internal Medicine

|June 1, 1984

Summary

This study observed persistent lymphadenopathy in homosexual men, finding immune dysfunction but not severe acquired immunodeficiency syndrome (AIDS) manifestations. The condition may represent an alternative response to the AIDS agent.

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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

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Published on: October 12, 2018

Area of Science:

Immunology
Virology
Epidemiology

Background:

Persistent unexplained lymphadenopathy was observed in homosexual men.
Demographic, clinical, and laboratory findings resembled those in acquired immunodeficiency syndrome (AIDS) patients.

Purpose of the Study:

To investigate the natural history of persistent diffuse lymphadenopathy in homosexual men.
To compare the clinical and immunological profiles of these patients with those of AIDS patients.

Main Methods:

Prospective natural history study involving 70 homosexual men.
Clinical evaluation, laboratory testing, and lymph node biopsy in 35 patients.

Main Results:

Lymph node biopsies showed florid follicular hyperplasia, a benign reactive finding.
Patients exhibited constitutional symptoms, recurrent infections, B-lymphocyte activation, and inverted T-helper:suppressor cell ratios.
None of the participants developed severe AIDS manifestations during the study period.

Conclusions:

The observed lymphadenopathy syndrome may represent an alternative clinical presentation of the acquired immunodeficiency syndrome agent.
This suggests the agent can induce varied immune responses and clinical outcomes.