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Related Concept Videos

Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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Fibrous Proteins00:55

Fibrous Proteins

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Related Experiment Video

Updated: Jul 12, 2026

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound
08:51

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound

Published on: May 8, 2012

Physiology of fibronectin.

D F Mosher

    Annual Review of Medicine
    |January 1, 1984
    PubMed
    Summary

    Fibronectin, a key protein in blood and tissues, plays a vital role in tissue remodeling during development and healing. While its functions are extensive, specific diseases linked to fibronectin abnormalities remain unidentified.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Physiology

    Background:

    • Fibronectin is a crucial protein found in blood and tissues.
    • It is extensively researched due to its numerous interactions with cells and macromolecules.
    • Fibronectin is a primary constituent of the extracellular matrix.

    Purpose of the Study:

    • To summarize the known functions and significance of fibronectin.
    • To highlight its role in critical physiological processes.
    • To discuss alterations in fibronectin in disease states.

    Main Methods:

    • Literature review of fibronectin research.
    • Analysis of fibronectin's interactions and functions.
    • Examination of fibronectin concentration and distribution in disease.

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    ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
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    ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

    Published on: April 17, 2014

    Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
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    Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

    Published on: May 10, 2020

    Related Experiment Videos

    Last Updated: Jul 12, 2026

    Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound
    08:51

    Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound

    Published on: May 8, 2012

    ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
    16:33

    ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

    Published on: April 17, 2014

    Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
    07:14

    Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

    Published on: May 10, 2020

    Main Results:

    • Fibronectin is essential for tissue remodeling in embryogenesis and wound healing.
    • It influences physiological processes such as phagocytosis.
    • Altered plasma and tissue fibronectin levels are observed in various diseases.

    Conclusions:

    • Fibronectin is a multifunctional protein with significant roles in tissue repair and development.
    • Despite observed changes in disease, no specific fibronectin-related disorders have been identified.
    • Further research may elucidate the precise role of fibronectin in specific pathologies.