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Updated: Jul 22, 2026

Respirometric Oxidative Phosphorylation Assessment in Saponin-permeabilized Cardiac Fibers
Published on: March 1, 2011
[Structural and kinetic parameters of the oxidative phosphorylation system, participating in the synchronization of
Abstract:
The structural and kinetic parameters of the oxidative phosphorylation system responsible for synchronization of the respiratory chain and ATP-synthetase function in mitochondria were studied. It was shown that regulation of ATP-synthetase function by the respiratory chain can be realized only within the whole ATP-synthetase complex (F0F1). NADH dehydrogenase and succinate dehydrogenase doe not control synchronization of ATP-synthetase function in the mitochondria. Data from the inhibitory analysis suggest that the ATP-synthetase function depends on the rate of the enzyme operation but not on the redox state of the respiratory chain carriers.
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