Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oophorectomy leads to a selective decrease in 1,25-dihydroxycholecalciferol receptors in rat jejunal villous cells.

S D Chan, D K Chiu, D Atkins

    Clinical Science (London, England : 1979)
    |June 1, 1984
    PubMed
    Summary

    Oophorectomy selectively reduces intestinal 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] receptors, suggesting a direct estrogen effect. This may explain reduced calcium absorption post-menopause.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patterns of adaptation to children's food allergies.

    Allergy·2015
    Same author

    Introduction.

    Journal of lesbian studies·2014
    Same author

    Synthesizing statistical knowledge from incomplete mixed-mode data.

    IEEE transactions on pattern analysis and machine intelligence·2011
    Same author

    Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1.

    Journal of medical genetics·2006
    Same author

    Laser microdissection and microarray analysis of breast tumors reveal ER-alpha related genes and pathways.

    Oncogene·2005
    Same author

    [Intraoperative histological sections in obstetric brachial plexus lesions--comparison of macroscopic appearance, HE staining and toluidine blue staining].

    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...·2003

    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Nutritional Science

    Background:

    • 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] is crucial for calcium absorption.
    • Oophorectomy and menopause are associated with decreased calcium absorption.
    • The role of estrogen in regulating intestinal vitamin D receptors is not fully understood.

    Purpose of the Study:

    • To investigate the effect of oophorectomy on 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] receptor distribution in rat jejunal cells.
    • To determine if estrogen directly influences intestinal 1,25-(OH)2D3 receptor synthesis.

    Main Methods:

    • Isolated rat jejunal cells were used.
    • Animals included normal, oophorectomized, and vitamin D-deficient female rats.
    • 1,25-(OH)2D3 receptor numbers were quantified.

    Related Experiment Videos

    Main Results:

    • Oophorectomy led to a significant (37%) reduction in 1,25-(OH)2D3 receptors in villous cells.
    • This reduction was observed in both normal and vitamin D-deficient animals.
    • The effect was independent of vitamin D status, suggesting a direct estrogenic influence.

    Conclusions:

    • Estrogen directly impacts the intestinal synthesis of 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] receptors.
    • This estrogen-mediated regulation may contribute to the impaired calcium absorption seen after oophorectomy or menopause.
    • Further research could explore therapeutic strategies targeting this pathway.