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Updated: Jul 17, 2026

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay
Published on: August 5, 2011
Feedback inhibition of erythropoiesis induced in anaemic Xenopus
Abstract:
Serum from normal Xenopus, when injected into anaemic Xenopus, causes reduction in both DNA and protein synthesis in erythroid cells as indicated by in vitro culture of the blood cells. Experiments with erythrocyte-conditioned medium, reveal that this inhibitory substance can be recovered from mature erythrocytes. Sephadex G-25 fractionation of normal serum and haemolysate demonstrates that the inhibitory factor consists of molecules of low molecular weight, and experiments with with cells of Xenopus kidney reveal that the feedback inhibition may be tissue specific to erythroid cells.
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Feedback Inhibition
Erythropoiesis
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...

