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Herpes simplex and recurrent corneal disease.

A H Wander

    International Ophthalmology Clinics
    |January 1, 1984
    PubMed
    Summary

    Managing ocular herpes simplex virus (HSV) requires vigilance. Early warning signs like redness, pain, or vision decrease prompt timely ophthalmologist consultation for recurrent ocular HSV infections.

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    Area of Science:

    • Ophthalmology
    • Virology
    • Immunology

    Background:

    • Ocular herpes simplex virus (HSV) infections present a significant management challenge for ophthalmologists due to variable clinical presentations and potential for painless recurrences.
    • Patients with a history of ocular HSV require close monitoring, especially during immunosuppressive therapy, due to increased risk of reactivation.

    Purpose of the Study:

    • To outline strategies for managing ocular HSV, emphasizing patient education on warning signs and the importance of seeking prompt medical attention.
    • To discuss prophylactic measures and the ongoing research into novel therapeutic and preventative strategies, including vaccines, for ocular HSV.

    Main Methods:

    • Educating patients on three key warning signs: eye redness, pain, or decreased vision.
    • Recommending prophylactic antiviral agents (e.g., trifluridine) for patients undergoing immunosuppression or with identified trigger mechanisms.
    • Discouraging cosmetic contact lens wear in susceptible patients to prevent minor trauma-induced recurrences.

    Main Results:

    • Current therapies have not definitively decreased HSV recurrence rates.
    • Prophylactic antiviral use is recommended during immunosuppression and steroid therapy.
    • Research into vaccines targeting viral proteins shows promise in preventing latency in experimental models.

    Conclusions:

    • Ophthalmologists must remain diligent in managing ocular HSV due to diverse recurrence patterns and potential complications.
    • Future research, including vaccine development and newer antiviral agents like acyclovir and interferon, holds promise for improved prevention and treatment.
    • Patient education on early warning signs is crucial for timely intervention in ocular HSV management.

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