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Related Experiment Videos

Gold induced encephalopathy: case report.

R P Perry, E S Jacobsen

    The Journal of Rheumatology
    |April 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Gold therapy for rheumatoid arthritis can cause serious neurologic disease, including encephalopathy and peripheral neuropathy. Prompt treatment with dimercaprol (BAL) chelation therapy led to symptom remission in this case.

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    Area of Science:

    • Neurology
    • Toxicology
    • Rheumatology

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
    • Gold compounds have been used therapeutically for RA.
    • Neurologic complications from gold therapy are rare but significant.

    Observation:

    • A patient with presumed RA developed severe neurologic symptoms.
    • Manifestations included encephalopathy, generalized muscle fasciculations, and peripheral neuropathy.
    • Symptoms emerged during treatment with therapeutic doses of gold.

    Findings:

    • The patient's neurologic illness showed prompt remission following dimercaprol (BAL) chelation therapy.
    • Dimercaprol effectively removed gold from the body.
    • This suggests a direct link between gold accumulation and neurotoxicity.

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    Implications:

    • Highlights the potential for gold-induced neurotoxicity in RA patients.
    • Emphasizes the importance of monitoring for neurologic adverse effects during gold therapy.
    • Dimercaprol (BAL) is a potential treatment for gold toxicity.
    • Further research is needed on the mechanisms of gold neurotoxicity.