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The cytogenetic basis for classifying ependymomas.

R L Friede, A Pollak

    Journal of Neuropathology and Experimental Neurology
    |March 1, 1978
    PubMed
    Summary
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    Ependymomas exhibit cellular structures resembling primitive ependymoglia, suggesting a reversion to an early developmental stage. Some tumors show transitional features, potentially representing a tanycytic variant of ependymomas, particularly in the spinal cord.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Pathology

    Background:

    • Ependymal cells and astrocytes originate from a common progenitor, ependymoglia or tanycytes.
    • Primitive ependymoglia cells possess astrocyte-like processes and glial footplates, persisting in mature mammalian brains.
    • Understanding glial cell phylogeny is crucial for diagnosing brain tumors.

    Purpose of the Study:

    • To investigate the cellular and structural characteristics of ependymomas using electron microscopy.
    • To determine if neoplastic cells in ependymomas exhibit features of primitive ependymoglia.
    • To identify and characterize potential transitional tumor types between ependymomas and astrocytomas.

    Main Methods:

    • Electron microscopic examination of 8 ependymomas.

    Related Experiment Videos

  • Review of histological features in 43 ependymomas and 71 astrocytomas.
  • Comparative analysis of tumor morphology with primitive glial cell structures.

    • Main Results:

    • Neoplastic cells in ependymomas display features consistent with primitive ependymoglia, including glial filaments and primitive footplates.
    • Perivascular pseudorosettes in ependymomas are identified as equivalents of primitive cell poles.
    • 11 tumors showed transitional structures, possibly representing a tanycytic variant of ependymomas, often found in the spinal cord.

    Conclusions:

    • Ependymoma structure reflects a reversion to the primitive ependymoglia stage.
    • A tanycytic variant of ependymomas exists, characterized by transitional features, and can be confused with piloid astrocytomas.
    • These findings enhance understanding of glial tumor origins and classification.