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tau, a repeated DNA sequence in yeast.

G E Chisholm, F S Genbauffe, T G Cooper

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1984
    PubMed
    Summary
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    Researchers discovered a novel 371-base-pair DNA element, named tau, in Saccharomyces cerevisiae. This transposable element shares structural similarities with other known mobile genetic elements and is found near transfer RNA genes.

    Area of Science:

    • Molecular Biology
    • Genetics
    • Yeast Biology

    Background:

    • Saccharomyces cerevisiae is a model organism for studying eukaryotic gene regulation and genome dynamics.
    • Transposable elements (TEs) are mobile DNA sequences that can alter genome structure and function.
    • Previous research identified various TEs in yeast, including Ty, sigma, and copia elements.

    Purpose of the Study:

    • To identify and characterize novel repeated DNA elements in Saccharomyces cerevisiae.
    • To elucidate the structural features and genomic location of the newly discovered tau element.
    • To compare the tau element with other known transposable elements in yeast.

    Main Methods:

    • DNA sequencing and analysis to determine the structure of the tau element.

    Related Experiment Videos

  • Sequence homology searches to compare tau with known repetitive DNA sequences.
  • Genomic mapping to identify the location of tau elements relative to other genes, particularly tRNA genes.

    • Main Results:

    • A 371-base-pair repeated DNA element, designated tau, was identified in Saccharomyces cerevisiae.
    • The tau element exhibits structural characteristics of transposable elements, including terminal inverted repeats and flanking direct repeats of target DNA.
    • Tau elements were found in both orientations and closely associated with transfer RNA (tRNA) genes.
    • One instance of concentric insertion involving tau, delta, and sigma elements was observed.

    Conclusions:

    • The tau element represents a novel transposable element in Saccharomyces cerevisiae.
    • Its structural features suggest a mechanism for transposition similar to other known mobile elements.
    • The association of tau with tRNA genes indicates potential roles in gene regulation or genome organization.