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Related Experiment Videos

Phencyclidine-induced immunodepression.

N Khansari, H D Whitten, H H Fudenberg

    Science (New York, N.Y.)
    |July 6, 1984
    PubMed
    Summary
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    Phencyclidine (PCP) can suppress immune cell function, impacting both its recreational abuse and clinical use in anesthesia. This immune depression may increase the risk of postoperative infections.

    Area of Science:

    • Neuroscience
    • Immunology
    • Pharmacology

    Background:

    • Phencyclidine (PCP), a psychotomimetic drug, has anesthetic applications.
    • PCP is known to block potassium ion channels and bind to lymphocytes.

    Purpose of the Study:

    • To investigate the effects of PCP on immunocyte function.
    • To assess the impact of PCP on humoral and cellular immune responses.

    Main Methods:

    • Treatment of immunocytes with PCP in vitro.
    • Evaluation of immune responses before biological assay.

    Main Results:

    • PCP treatment significantly depressed humoral and cellular immune responses in vitro.
    • Specific binding of PCP to lymphocytes was observed.

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    Conclusions:

    • PCP's immunomodulatory effects have implications for its abuse.
    • PCP derivatives used in anesthesia may increase the risk of postoperative infections due to immune suppression.