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Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters
Advances in Cyclic Nucleotide and Protein Phosphorylation Research
|January 1, 1984
Abstract:
The phorbol ester TPA may be intercalated into the membrane phospholipid bilayer and selectively binds to every molecule of C-kinase in exhibiting its full enzymatic activity. Available evidence suggests that C-kinase is the receptive protein of this tumor promoter, and the results presented seem to provide clues for clarifying the mechanism of controlling cell growth and differentiation.