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Related Experiment Videos

Oral ranitidine in labour.

D M McAuley, J Moore, J W Dundee

    Anaesthesia
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Ranitidine administration in laboring women did not increase operative interventions or postpartum complications. While some women had reduced gastric pH, infant outcomes and gastrointestinal colonization remained unaffected, with minimal neonatal ranitidine exposure.

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    Area of Science:

    • Obstetrics and Gynecology
    • Pharmacology
    • Anesthesiology

    Background:

    • Maternal aspiration during anesthesia is a significant risk in obstetrics.
    • Prophylactic medications are used to reduce gastric acidity and volume.
    • Ranitidine is a histamine H2-receptor antagonist with potential use in labor.

    Purpose of the Study:

    • To evaluate the efficacy and safety of oral ranitidine in laboring women.
    • To compare ranitidine's effects on maternal and neonatal outcomes with conventional alkali therapy.
    • To assess ranitidine's impact on gastric pH, volume, and neonatal parameters.

    Main Methods:

    • A randomized controlled trial involving 909 women receiving ranitidine and 378 controls receiving alkali therapy.
    • Maternal outcomes included operative interventions, placental retention, and postpartum hemorrhage.

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  • Gastric pH and volume were measured during emergency anesthesia; neonatal Apgar scores and ranitidine levels were assessed.

    • Main Results:

    • No significant differences in operative intervention, placental retention, or postpartum hemorrhage between groups.
    • Slightly lower mean gastric volume in the ranitidine group (83 ml) vs. control (122 ml).
    • Minimal ranitidine detected in neonatal blood; no adverse effects on Apgar scores or gastrointestinal colonization.

    Conclusions:

    • Oral ranitidine is a safe and effective option for reducing gastric volume in laboring women.
    • Ranitidine does not negatively impact maternal or neonatal outcomes.
    • Further research may explore optimal dosing and timing in obstetric anesthesia.