Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coupled oscillators in an isolated pacemaker neuron?

W Buño, J Fuentes

    Brain Research
    |June 11, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Briefly lengthening crayfish stretch receptors affects their firing patterns. Larger perturbations are phase-independent, while smaller ones depend on timing, suggesting a two-oscillator model for pacemaker activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term effectiveness and safety of colonoscopy-guided Fecal Microbiota Transplantation in recurrent Clostridiodes difficile infection: a prospective case series.

    Gastroenterologia y hepatologia·2026
    Same author

    Assessment of low dietary inclusion of nutraceuticals derived from microalgae to enhance intestinal function in gilthead seabream (Sparus aurata) juveniles.

    Scientific reports·2026
    Same author

    Effect of bile salts on intestinal epithelial function in gilthead seabream (Sparus aurata).

    Fish physiology and biochemistry·2024
    Same author

    [Transition challenges to integrate adults' rehabilitation within the multimorbidity approach in Chile].

    Rehabilitacion·2024
    Same author

    Longitudinal outcomes of obeticholic acid therapy in ursodiol-nonresponsive primary biliary cholangitis: Stratifying the impact of add-on fibrates in real-world practice.

    Alimentary pharmacology & therapeutics·2024
    Same author

    Editorial: Microbiome dynamics as biomarkers of welfare status in aquatic species.

    Frontiers in physiology·2023
    Same journal

    IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

    Brain research·2026
    Same journal

    Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

    Brain research·2026
    Same journal

    Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

    Brain research·2026
    Same journal

    Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

    Brain research·2026
    Same journal

    Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

    Brain research·2026
    Same journal

    Emotions, the amygdala, and the right hemisphere.

    Brain research·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Biophysics

    Background:

    • The slowly adapting stretch receptor organ (SAR) in crayfish exhibits pacemaker activity.
    • Understanding the mechanisms governing SAR pacemaker activity is crucial for neuroscience and biophysics.

    Purpose of the Study:

    • To investigate the effects of brief lengthening perturbations of varying amplitudes on crayfish SAR pacemaker activity.
    • To elucidate the phase-dependence and compensation mechanisms in SAR response to perturbations.

    Main Methods:

    • Analysis of pacemaker activity in crayfish SAR.
    • Application of brief lengthening perturbations with different amplitudes.
    • Phase-dependent and phase-independent analysis of interspike intervals.

    Main Results:

    Related Experiment Videos

    • Low-amplitude perturbations showed phase-dependent effects, while high-amplitude perturbations were phase-independent.
    • Perturbations decreased the interspike interval, anticipating the next spike.
    • Post-perturbation intervals showed phase-dependent lengthening that gradually decreased.
    • Phase compensation was observed, with recovery of pre-perturbation firing phase.

    Conclusions:

    • Crayfish SAR pacemaker activity is influenced by perturbation amplitude and timing.
    • Phase compensation suggests the involvement of at least two underlying oscillators: one unperturbable and one stimulus-sensitive.