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Related Experiment Videos

Ranitidine in reflux oesophagitis. A double-blind placebo-controlled study.

K R Hine, G K Holmes, V Melikian

    Digestion
    |January 1, 1984
    PubMed
    Summary

    Ranitidine significantly improved symptoms and healing in patients with reflux oesophagitis. This medication offers value in managing oesophageal reflux and potentially preventing peptic stricture development.

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    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Symptomatic oesophageal reflux (GERD) significantly impacts patient quality of life.
    • Reflux oesophagitis requires effective therapeutic interventions.

    Purpose of the Study:

    • To evaluate the efficacy of ranitidine in managing symptomatic oesophageal reflux.
    • To assess ranitidine's impact on pain relief, endoscopic healing, and histological improvement.

    Main Methods:

    • A double-blind, comparative trial involving 46 patients.
    • Comparison of a twice-daily 150 mg dose of ranitidine against a placebo.

    Main Results:

    • Ranitidine treatment resulted in significant relief of pain.
    • Endoscopic healing and histological improvement were notably better with ranitidine.

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  • Statistically significant improvements observed in the ranitidine group.

    • Conclusions:

    • Ranitidine demonstrates significant value in the management of reflux oesophagitis.
    • Ranitidine may play a role in preventing the progression to peptic stricture.