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Related Experiment Videos

Iron burden in sickle cell anemia.

R T O'Brien

    The Journal of Pediatrics
    |April 1, 1978
    PubMed
    Summary

    Patients with sickle cell anemia generally do not accumulate excess iron early in life. Serum ferritin levels correlate with age, and iron excretion is lower than in thalassemia major patients.

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    EFFECTS OF DEUTERIUM OXIDE AND RADIATION ON YEAST AND FISH. HW-76000.

    HW-SA [reports]. U.S. Atomic Energy Commission·2014

    Area of Science:

    • Hematology
    • Iron Metabolism

    Background:

    • Sickle cell anemia is a chronic condition.
    • Iron overload is a concern in chronic diseases, particularly those requiring transfusions.

    Purpose of the Study:

    • To assess total body iron burden in patients with sickle cell anemia.
    • To evaluate the relationship between age and serum ferritin levels.
    • To compare iron excretion in sickle cell anemia patients with those of thalassemia major.

    Main Methods:

    • Indirect estimation of total body iron burden.
    • Measurement of serum ferritin concentrations.
    • Assessment of deferoxamine-induced urinary iron excretion.

    Main Results:

    • Serum ferritin levels showed a significant positive correlation with patient age.
    • A majority of patients under 20 years had normal serum ferritin levels.
    • Urinary iron excretion was lower compared to regularly transfused thalassemia major patients.

    Conclusions:

    • Sickle cell anemia patients typically do not develop significant iron overload in the first two decades of life.
    • The risk of transfusional hemosiderosis in sickle cell anemia requires careful consideration within hypertransfusion programs.

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