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Systemic infection by Rhodotorula spp. in the immunocompromised host
The Journal of Infection
|May 1, 1984
Summary
Systemic Rhodotorula infection is a serious risk for immunocompromised patients, particularly those with acute myelogenous leukemia. Aggressive antifungal and antileukemia treatment can successfully eradicate this invasive fungal disease.
Area of Science:
- Mycology
- Hematology
- Infectious Diseases
Background:
- Invasive fungal infections pose a significant threat to immunocompromised individuals.
- Acute myelogenous leukemia (AML) patients are particularly susceptible to opportunistic infections.
Observation:
- A case of systemic Rhodotorula infection occurred in a patient with AML.
- Rhodotorula was repeatedly isolated from bone marrow despite amphotericin B treatment.
- Liver abscesses were suspected on CT scan and confirmed by biopsy.
Findings:
- Rhodotorula fungemia can cause invasive disease in immunocompromised hosts.
- The yeast was isolated from bone marrow twice, indicating persistent infection.
- Successful eradication was achieved with combined aggressive antifungal and antileukemia therapy.
Implications:
- Rhodotorula should be considered in the differential diagnosis of invasive fungal disease in immunocompromised patients.
- Prompt and aggressive treatment is crucial for managing Rhodotorula infections.
- This case highlights the potential severity and treatability of Rhodotorula fungemia in vulnerable populations.