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Cefmenoxime (CMX) is rapidly excreted in children aged 8-13 after a 50 mg/kg dose, with both intravenous injection and drip infusion showing quick elimination and short biological half-lives for this antibiotic.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Antibiotic Research
Context:
- Cefmenoxime (CMX) is a third-generation cephalosporin antibiotic.
- Pediatric dosing and pharmacokinetic data are crucial for effective and safe antibiotic use.
- Understanding drug elimination is vital for optimizing treatment regimens.
Purpose:
- To evaluate the blood levels and urinary excretion of cefmenoxime (CMX) in pediatric patients.
- To compare the pharmacokinetics of CMX following intravenous injection versus 1-hour drip infusion.
- To determine the biological half-life and excretion rates of CMX in children aged 8 to 13 years.
Summary:
- Children (8-13 years) received a 50 mg/kg dose of cefmenoxime (CMX) via intravenous injection or 1-hour drip infusion.
- Intravenous injection resulted in mean blood levels of 125.0 µg/ml at 0.5 hours, with a half-life of ~0.7 hours and 64.1% urinary excretion by 6 hours.
- Drip infusion showed mean levels of 115.5 µg/ml post-infusion, a half-life of ~0.8 hours, and 56.5% urinary excretion by 6 hours.
Impact:
- Cefmenoxime (CMX) demonstrates rapid excretion in pediatric patients at a high dosage.
- The findings suggest that CMX is eliminated quickly, influencing potential redosing strategies.
- This pharmacokinetic data aids in understanding CMX behavior in children, informing clinical practice.
Abstract:
Blood levels and urinary excretion of cefmenoxime (CMX) in children of 8 to 13 years old who received 50 mg/kg of CMX by one shot intravenous injection or 1-hour drip infusion were evaluated. One shot intravenous injection (1) Blood levels--The mean blood levels in 2 cases by intravenous injection were 125.0 +/- 24.0, 56.8 +/- 10.0, 17.8 +/- 6.2, 2.2 +/- 0.7 and 0.4 +/- 0.2 micrograms/ml, after 1/2, 1, 2, 4 and 6 hours, respectively. The mean biological half-life was approximately 0.7 hour. (2) Urinary excretion--The average urinary excretion rate in 2 cases were 57.8, 63.9 and 64.1% after 2, 4 and 6 hours, respectively. 1-hour drip infusion (1) Blood levels--The mean blood levels in 2 cases by drip infusion were 115.5 +/- 0.5, 29.05 +/- 0.25, 5.0 +/- 0.8 and 1.15 +/- 0.45 micrograms/ml, immediately after the completion of infusion, after 1, 3 and 5 hours, respectively. The mean biological half-life after drip infusion was approximately 0.8 hour. (2) Urinary excretion--The average urinary excretion rate in 2 cases were 42.2, 55.5 and 56.5% after 2, 4 and 6 hours, respectively. On the basis of these results, it was concluded that CMX was excreted relatively rapidly in a massive dose of 50 mg/kg a time.