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Related Experiment Videos

[Basic studies of cefmenoxime].

T Aoyama

    The Japanese Journal of Antibiotics
    |March 1, 1984
    PubMed
    Summary

    Cefmenoxime (CMX) is rapidly excreted in children aged 8-13 after a 50 mg/kg dose, with both intravenous injection and drip infusion showing quick elimination and short biological half-lives for this antibiotic.

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    [Catastrophic pulmonary vasoconstriction associated with protamine reversal of heparin].

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    Area of Science:

    • Pharmacology
    • Pediatric Medicine
    • Antibiotic Research

    Context:

    • Cefmenoxime (CMX) is a third-generation cephalosporin antibiotic.
    • Pediatric dosing and pharmacokinetic data are crucial for effective and safe antibiotic use.
    • Understanding drug elimination is vital for optimizing treatment regimens.

    Purpose:

    • To evaluate the blood levels and urinary excretion of cefmenoxime (CMX) in pediatric patients.
    • To compare the pharmacokinetics of CMX following intravenous injection versus 1-hour drip infusion.
    • To determine the biological half-life and excretion rates of CMX in children aged 8 to 13 years.

    Summary:

    • Children (8-13 years) received a 50 mg/kg dose of cefmenoxime (CMX) via intravenous injection or 1-hour drip infusion.
    • Intravenous injection resulted in mean blood levels of 125.0 µg/ml at 0.5 hours, with a half-life of ~0.7 hours and 64.1% urinary excretion by 6 hours.
    • Drip infusion showed mean levels of 115.5 µg/ml post-infusion, a half-life of ~0.8 hours, and 56.5% urinary excretion by 6 hours.

    Impact:

    • Cefmenoxime (CMX) demonstrates rapid excretion in pediatric patients at a high dosage.
    • The findings suggest that CMX is eliminated quickly, influencing potential redosing strategies.
    • This pharmacokinetic data aids in understanding CMX behavior in children, informing clinical practice.

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