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Breast cancer multicentricity.

R W McDivitt

    Monographs in Pathology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Breast cancer multicentricity occurs in 25-50% of cases, with 5-10% being invasive. Understanding this is crucial for effective breast cancer treatment and recurrence prevention.

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    Area of Science:

    • Oncology
    • Pathology

    Background:

    • Breast cancer multicentricity rates vary based on detection methods, distance criteria for secondary tumors, and inclusion of in situ carcinomas.
    • Factors like primary tumor stage and histology influence multicentricity incidence.

    Purpose of the Study:

    • To estimate the overall incidence of breast cancer multicentricity.
    • To characterize the nature and location of multicentric breast cancers.
    • To discuss implications for breast cancer treatment, particularly tylectomy.

    Main Methods:

    • Review of existing literature and data on breast cancer multicentricity.
    • Analysis of factors influencing reported incidence rates.
    • Estimation of the range for overall multicentricity and invasive components.

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    Main Results:

    • Estimated overall breast cancer multicentricity rate is 25-50%.
    • Approximately 5-10% of multicentric breast cancers are invasive.
    • Multicentric tumors can occur outside the primary quadrant and near the nipple.

    Conclusions:

    • High incidence of multicentricity suggests significant ipsilateral breast recurrence risk after tylectomy.
    • The impact of multicentric recurrences on breast cancer mortality remains unknown.
    • Radiation therapy may reduce short-term recurrence, but long-term survival effects with combined treatments are unclear.