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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.

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Raf-1 protein kinase activity in T cells from aged mice.

Methods in molecular medicine·2012

Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.

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Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption.

The Journal of steroid biochemistry and molecular biology·2007

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Macroscopic to ultrastructural analyses identify the loss of myofibrils as the primary mediator of ageing- and disuse-induced muscle fibre atrophy.

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Architecture of the cardiac transverse-axial tubular system across different mammalian species.

The Journal of physiology·2026

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions.

The Journal of physiology·2026

A structure-based model that describes activation and inactivation of a sodium channel.

The Journal of physiology·2026

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The Journal of physiology·2026

The influence of force on the encoding and perception of affective touch.

The Journal of physiology·2026

Lipases: An Overview.

Methods in molecular biology (Clifton, N.J.)·2026

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ACS omega·2026

Spatiotemporal Sequential Fluorescence and Electrochemistry Bimodal Quantitation of Enzyme Activity in a Living Cell.

Nano letters·2026

Milestones in the Elucidation of Heme Biosynthesis.

Chemical reviews·2026

Heme Peroxo Reaction Intermediates: Mimicking Biological Structure and Reactivity With Synthetic Model Systems.

Angewandte Chemie (International ed. in English)·2026

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The use of the perfused liver or hepatocyte suspensions for the study of hepatic function [proceedings]

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A novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity.

The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.

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The use of the perfused liver or hepatocyte suspensions for the study of hepatic function [proceedings]

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