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Adrenergic function in patients with panic anxiety.

R M Nesse, O G Cameron, G C Curtis

    Archives of General Psychiatry
    |August 1, 1984
    PubMed
    Summary
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    Patients with panic disorder may have decreased, not increased, beta-adrenergic receptor sensitivity. This may be due to receptor down-regulation from elevated adrenergic function, even without panic attacks.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Panic disorder is hypothesized to involve increased beta-adrenergic receptor sensitivity.
    • Understanding adrenergic function is crucial for panic disorder research.

    Purpose of the Study:

    • To investigate beta-adrenergic receptor sensitivity in patients with panic disorder.
    • To compare adrenergic function between panic disorder patients and healthy controls.

    Main Methods:

    • Compared 14 panic disorder patients with 6 healthy controls.
    • Measured heart rate, blood pressure, and plasma hormone levels (epinephrine, norepinephrine, cortisol, growth hormone).
    • Administered intravenous isoproterenol hydrochloride to assess beta-adrenergic response.

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    Main Results:

    • Panic disorder patients exhibited elevated resting heart rate and plasma epinephrine, cortisol, and growth hormone levels.
    • Plasma norepinephrine levels were mildly elevated in patients.
    • Patients showed decreased heart rate response to isoproterenol, suggesting reduced beta-adrenergic sensitivity.

    Conclusions:

    • Beta-adrenergic receptor sensitivity appears decreased, not increased, in panic disorder patients.
    • Elevated adrenergic function may lead to receptor down-regulation in panic disorder.
    • Findings challenge the hypothesis of increased beta-adrenergic sensitivity in panic disorder.