Release of serotonin from perikarya in cat nodose ganglia

Newly synthesized serotonin (5-HT) can be released in the nodose ganglion from the nerve cell bodies of vago-aortic serotoninergic neurones. Free-calcium led to a decrease of spontaneous and potassium-evoked release. The veratridine-stimulating response was abolished by TTX. The concept that 5-HT released from perikarya in the extracellular space could be involved in the self-regulation of the activity of the vago-aortic pathway is discussed.