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Non-asbestos-related malignant mesothelioma. A review
Abstract:
Malignant mesothelioma is an uncommon, but increasingly important, neoplasm. The existing English-language medical literature concerning non-asbestos-related malignant mesotheliomas was reviewed for evidence of other agents associated with the induction of malignant mesothelioma. Both animal and human data were reviewed. In most reviews of malignant mesothelioma, there are a significant proportion of cases without documented asbestos exposure (range, 0% to 87%). Furthermore, there are several fairly well-documented agents other than asbestos that induce malignant mesothelioma in animals, and strong evidence exists that such is the case in man. In reviews of malignant mesothelioma, the percentage of cases with asbestos exposure varies, but a significant number are apparently not asbestos related. It is believed that sufficient evidence exists to suggest that non-asbestos agents can induce malignant mesotheliomas in man, and additional epidemiologic studies in this area are needed.
Insights
Non-asbestos agents can cause malignant mesothelioma, a rare cancer. Research indicates other environmental factors, besides asbestos, are linked to this cancer, necessitating further study.
Area of Science:
- Oncology
- Environmental Health
Background:
- Malignant mesothelioma is an uncommon neoplasm.
- A significant proportion of cases lack documented asbestos exposure.
Purpose of the Study:
- To review the medical literature for non-asbestos agents associated with malignant mesothelioma.
- To assess evidence from animal and human data.
Main Methods:
- Systematic review of English-language medical literature.
- Analysis of both animal and human data regarding mesothelioma induction.
Main Results:
- Several agents besides asbestos are documented to induce malignant mesothelioma in animals.
- Strong evidence suggests non-asbestos agents can induce malignant mesothelioma in humans.
- Reported asbestos exposure varies significantly across studies (0% to 87%).
Conclusions:
- Sufficient evidence suggests non-asbestos agents can induce malignant mesothelioma in humans.
- Further epidemiologic studies are needed to identify non-asbestos causative agents.