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Updated: Aug 15, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

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Published on: May 27, 2011

Dk-restricted antiinfluenza cytotoxic T-cell clone loses one of its two alloreactivities

D C Wraith

    Immunogenetics
    |January 1, 1984
    PubMed

    K6, an influenza-specific cytotoxic T (Tc)-cell clone derived from C3H/He mice, was Dk-restricted. Further analysis showed that K6 also recognized Dd and Dq as allotargets. The clonal nature of the three recognition specificities was confirmed by cold-target cell inhibition. After extensive in vitro selection, K6 lost the ability to lyse Dd cells while retaining both other specificities. The role of the Lyt-2 molecule in antigen-specific self-H-2-restricted vs allospecific recognition was investigated by inhibition with the Lyt-2-specific monoclonal antibody 53-6.7. Both activities were proportionately inhibited, indicating that the Lyt-2 molecule is equally important for both recognition specificities of this Tc-cell clone.

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