Early plasma protein and mineral changes after surgery: a two stage process

Area of Science:

• Biochemistry
• Physiology
• Surgical Research

Background:

• Trauma triggers complex physiological responses affecting plasma protein and metal concentrations.
• Understanding these dynamic changes is crucial for managing surgical patients.

Purpose of the Study:

• To investigate the sequential changes in key plasma proteins and trace elements following hysterectomy.
• To elucidate the underlying mechanisms of early and late post-traumatic plasma alterations.

Main Methods:

• Plasma samples were collected sequentially up to 24 hours after hysterectomy.
• Concentrations of albumin, transferrin, alpha 1-acid glycoprotein, C-reactive protein, fibrinogen, copper, iron, and zinc were measured.

Main Results:

• A significant early (2-4h) decrease in albumin, transferrin, iron, zinc, and copper was observed.
• Acute phase proteins (alpha 1-acid glycoprotein, C-reactive protein, fibrinogen) increased after 6 hours, preceded by a fall.
• Metal-to-binding protein ratios decreased later (4-6h), with sustained low levels for 24 hours.

Conclusions:

• Early plasma protein and metal decrease suggests increased microvascular permeability post-trauma.
• Later changes indicate a potential common mediator initiating acute phase protein response and altered metal binding.