Comparison of delayed type hypersensitivity and T subsets in random and homosexual populations in western Australia

Random and homosexual populations were tested for delayed type hypersensitivity (DTH) (Multitest) reactivity and T cell subsets. In the random population DTH reactivity was stronger in males irrespective of age. Reactivity in the homosexuals was generally even stronger especially with respect to tuberculin. As a group, male homosexuals had low OKT 4/8 ratios when compared with sex and age matched controls. Analysis of DTH and T cell subset results in the random group showed an association between anergy and low OKT 4/8 ratios. It is concluded that homosexuals demonstrate some alteration of cell mediated immunity and therefore may be at risk of various infections.