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Antibodies to native and denatured type II collagen in children with rheumatic diseases

A M Rosenberg, D W Hunt, R E Petty

    The Journal of Rheumatology
    |August 1, 1984
    PubMed

    Insights

    Children with rheumatic diseases, including juvenile rheumatoid arthritis, show higher levels of antibodies to type II collagen (IIC). This finding suggests a potential link between IIC antibodies and various pediatric rheumatic conditions.

    Area of Science:

    • Immunology
    • Rheumatology
    • Pediatric Medicine

    Background:

    • Rheumatic diseases in children encompass a range of autoimmune and inflammatory conditions.
    • Type II collagen (IIC) is a major structural protein in cartilage, making it a potential autoantigen in joint diseases.
    • Antibodies to native (n) and denatured (d) forms of IIC may play a role in the pathogenesis of rheumatic diseases.

    Purpose of the Study:

    • To investigate the prevalence of antibodies to native and denatured type II collagen (IIC) in children with rheumatic diseases.
    • To compare antibody levels in children with various rheumatic conditions to those in non-rheumatic control groups.

    Main Methods:

    • Sera from 153 children with rheumatic diseases were analyzed using enzyme-linked immunosorbent assay (ELISA).
    • Antibodies to native (n) and denatured (d) type II collagen (IIC) were quantified.
    • Comparison was made with sera from non-rheumatic disease control groups.

    Main Results:

    • Antibodies to nIIC were detected in 47% of children with juvenile rheumatoid arthritis (JRA), 70% with adult-onset RA, and 21-37% with other rheumatic diseases.
    • Antibodies to dIIC showed similar prevalence, found in 42% of JRA patients and 67% of adult-onset RA patients.
    • Prevalence of both antibody types was significantly higher in rheumatic disease groups compared to controls (less than 1-6%).

    Conclusions:

    • Children with a variety of rheumatic diseases exhibit a significantly higher frequency of antibodies to both native and denatured type II collagen (IIC).
    • These findings suggest that IIC antibodies may be implicated in the development or progression of pediatric rheumatic diseases.
    • Further research is warranted to explore the specific role of IIC antibodies in the immunopathogenesis of childhood rheumatic conditions.

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