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Phrenic nerve stimulation (diaphragm pacing) in chronic singultus
Summary
A diaphragm pacer and electrophrenic stimulation offered relief for intractable hiccups in a patient with insomnia. This intervention shows promise for managing chronic hiccups by potentially interfering with abnormal phrenic nerve activation.
Area of Science:
- Neurology
- Medical Devices
Background:
- Continuous hiccups can lead to significant patient distress, including insomnia.
- Idiopathic hiccups present a diagnostic and therapeutic challenge.
Observation:
- A 71-year-old male patient experienced intractable hiccups for two years, causing insomnia.
- Preoperative phrenic nerve stimulation caused diaphragm contractions but did not alleviate hiccups.
Findings:
- Post-implantation of a diaphragm pacer, the patient experienced symptom relief.
- Subsequent electrophrenic stimulation led to the disappearance of hiccups.
- Hiccups recurred upon cessation of stimulation, suggesting a direct effect.
- The patient reported daytime hiccups only while using the pacer, with nocturnal relief and improved sleep.
Implications:
- Diaphragm pacing may offer a novel therapeutic approach for intractable hiccups.
- Phrenic nerve stimulation could modulate abnormal neural pathways responsible for hiccups.
- Further research is warranted to explore the mechanism and efficacy of diaphragm pacing for hiccup management.