Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The evolution of histones.

G R Reeck, E Swanson, D C Teller

    Journal of Molecular Evolution
    |February 21, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Newly developed methods revealed significant similarities among core histone sequences (H2A, H2B, H3, H4), suggesting a common evolutionary origin. Histone H1 showed no such similarities, indicating distinct evolutionary paths for core and H1 histones.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A cryogenic torsion balance using a liquid-cryogen free, ultra-low vibration cryostat.

    The Review of scientific instruments·2022
    Same author

    Delivery of lethal dsRNAs in insect diets by branched amphiphilic peptide capsules.

    Journal of controlled release : official journal of the Controlled Release Society·2018
    Same author

    OCT-based microangiography for reactive hyperaemia assessment within residual limb skin of people with lower limb loss.

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2017
    Same author

    A clinically realistic large animal model of intra-articular fracture that progresses to post-traumatic osteoarthritis.

    Osteoarthritis and cartilage·2015
    Same author

    Nucleotide and predicted amino acid sequences of two different genes for high-pI α-amylases from barley.

    Plant molecular biology·2013
    Same author

    Thermodynamic studies of concanavalin a dimer-tetramer equilibria.

    Biophysical journal·2009
    Same journal

    Sensing Underwater: Diversifying Selection, Convergent Evolution and Inactivation in Sensory Receptors' Genes of Aquatic Mammals.

    Journal of molecular evolution·2026
    Same journal

    Synonymous Codons as Potential Contributors to Chromatin Stability and Gene Body Methylation in Plants.

    Journal of molecular evolution·2026
    Same journal

    Convergent Functional Genomic Evolution Underlying Repeated Freshwater Colonization in Cetaceans.

    Journal of molecular evolution·2026
    Same journal

    Conditions Enabling the Persistence of Cooperating Synthetase, Ligase, and Mutation-Inhibitor Catalytic Polymers.

    Journal of molecular evolution·2026
    Same journal

    Lineage-Specific Diversification of Nucleoporin Nup98 Genes in Ciliates and Its Evolutionary Implications for the Nuclear Dualism.

    Journal of molecular evolution·2026
    Same journal

    Mitochondrial Genome Evolution: The Influence of Partitioning, Calibration, and Gene Heterogeneity on Pleurodontan Substitution Rates.

    Journal of molecular evolution·2026
    See all related articles

    Area of Science:

    • Molecular Biology
    • Evolutionary Biology
    • Biochemistry

    Background:

    • Histones are crucial proteins involved in DNA packaging.
    • Understanding histone evolution provides insights into chromatin structure and function.
    • Previous studies had not fully explored sequence similarities among core histones.

    Purpose of the Study:

    • To investigate potential sequence similarities among bovine core histones (H2A, H2B, H3, H4) and rabbit thymus histone H1.
    • To evaluate the statistical significance of observed sequence similarities.
    • To infer evolutionary relationships between different histone types.

    Main Methods:

    • Utilized newly developed procedures for detecting weak sequence similarities.
    • Employed the McLachlan scoring system for statistical evaluation.

    Related Experiment Videos

  • Analyzed amino acid sequences of bovine histones H2A, H2B, H3, H4, and rabbit H1.

    • Main Results:

    • Statistically significant sequence similarities were identified between pairs of the four core histones (H2A, H2B, H3, H4).
    • The probability of these similarities occurring by chance was extremely low (< 10^-5).
    • No significant sequence similarity was detected between histone H1 and the core histones.

    Conclusions:

    • The findings strongly suggest that the core histones evolved from a common ancestral protein.
    • The C-terminal portions of core histones appear to share a conserved evolutionary history.
    • Histone H1 likely followed a different evolutionary trajectory compared to the core histones.