Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tiaprofenic acid overdose.

C Köppel, A Wagemann, J Tenczer

    Arzneimittel-Forschung
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    A 14-year-old girl tolerated a 2000 mg tiaprofenic acid dose without intoxication. Analysis revealed known and a novel decomposition product in urine, with a new HPLC assay developed for plasma drug quantification.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Scope and limitations of a general unknown screening by gas chromatography-mass spectrometry in acute poisoning.

    Journal of the American Society for Mass Spectrometry·2013
    Same author

    Long- and short-term in vitro D-dimer stability measured with INNOVANCE D-Dimer.

    Thrombosis and haemostasis·2010
    Same author

    Pro- and antifibrinolytic properties of human pulmonary microvascular versus artery endothelial cells: impact of endotoxin and tumor necrosis factor-alpha.

    Critical care medicine·2004
    Same author

    Statins differ in their ability to block NF-kappaB activation in human blood monocytes.

    International journal of clinical pharmacology and therapeutics·2003
    Same author

    Cell-based delivery of cytokines allows for the differentiation of a doxycycline inducible oligodendrocyte precursor cell line in vitro.

    The journal of gene medicine·2002
    Same author

    Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14.

    American journal of physiology. Lung cellular and molecular physiology·2001

    Area of Science:

    • Pharmacology
    • Analytical Chemistry
    • Toxicology

    Background:

    • Tiaprofenic acid (Surgam) is a nonsteroidal anti-inflammatory drug (NSAID).
    • Assessing drug metabolism and potential toxicity after overdose is crucial.
    • Gas chromatography/mass spectrometry (GC/MS) is a standard analytical technique.

    Observation:

    • A 14-year-old female ingested 2000 mg of tiaprofenic acid.
    • The patient exhibited no signs of systemic intoxication despite the high dose.
    • Urine analysis was performed to identify the drug and its byproducts.

    Findings:

    • Tiaprofenic acid, its known metabolites, and chemical decomposition products were identified in the patient's urine via GC/MS.
    • A previously unidentified decomposition product of a tiaprofenic acid metabolite was detected.

    Related Experiment Videos

  • A rapid and sensitive high-performance liquid chromatography (HPLC) method was developed for quantifying tiaprofenic acid in plasma.

    • Implications:

    • This study highlights the metabolic profile of tiaprofenic acid, including novel decomposition pathways.
    • The development of a sensitive HPLC assay facilitates accurate therapeutic drug monitoring.
    • Understanding drug metabolism and decomposition is vital for managing overdose cases and ensuring patient safety.