Salt loss in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency

Nine patients with 11 beta-hydroxylase deficiency had 13 episodes of gastroenteritis requiring hospital admission and fluid administration. Eight episodes were accompanied by hyponatraemia and salt loss. The salt losing patients were treated with excessive glucocorticoid and those with normal serum sodium concentrations were treated with inadequate glucocorticoid. Excessive glucocorticoid suppressed deoxycorticosteroid secretion, resulting in salt loss.