Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell subsets in patients with aplastic anemia.

R P Falcão, J C Voltarelli, C Bottura

    Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
    |January 1, 1984
    PubMed
    Summary

    Aplastic anemia may involve abnormal T cell subsets. This study found normal absolute numbers but altered percentages of T mu and T gamma lymphocytes in most patients, suggesting potential immune system involvement in the disease pathogenesis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A.

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2017
    Same author

    Defective expression of apoptosis-related molecules in multiple sclerosis patients is normalized early after autologous haematopoietic stem cell transplantation.

    Clinical and experimental immunology·2016
    Same author

    Resolution of macular oedema associated with retinitis pigmentosa after intravitreal use of autologous BM-derived hematopoietic stem cell transplantation.

    Bone marrow transplantation·2012
    Same author

    Comparative analysis of the pathological events involved in immune and non-immune TRALI models.

    Vox sanguinis·2012
    Same author

    Up-regulation of fas and fasL pro-apoptotic genes expression in type 1 diabetes patients after autologous haematopoietic stem cell transplantation.

    Clinical and experimental immunology·2012
    Same author

    Mobilization and harvesting of PBPC in newly diagnosed type 1 diabetes mellitus.

    Bone marrow transplantation·2011

    Area of Science:

    • Immunology
    • Hematology
    • Cell Biology

    Background:

    • Lymphocyte subpopulation abnormalities are noted in aplastic anemia.
    • Previous studies suggest immune system involvement in aplastic anemia.

    Purpose of the Study:

    • To measure T cell subsets, specifically T mu-lymphocytes and T gamma-lymphocytes, in patients with aplastic anemia.
    • To investigate the relationship between T cell subset percentages and serum immunoglobulin levels in aplastic anemia.
    • To discuss the pathogenesis of aplastic anemia in light of observed immunological abnormalities.

    Main Methods:

    • Quantification of T mu-lymphocytes and T gamma-lymphocytes in 22 aplastic anemia patients and 48 healthy controls.
    • Analysis of the percentages and absolute numbers of T cell subsets.

    Related Experiment Videos

  • Correlation analysis between T mu/T gamma ratio and serum immunoglobulin levels.

    • Main Results:

    • The absolute numbers of T mu and T gamma lymphocytes were within normal ranges for most patients.
    • Elevated percentages of T mu cells were observed in 4 patients, and decreased in 2.
    • Increased percentages of T gamma cells were found in 6 patients.
    • No correlation was found between serum immunoglobulin levels and the T mu/T gamma ratio.

    Conclusions:

    • While absolute T cell counts may be normal, altered percentages of T mu and T gamma lymphocytes suggest potential immune dysregulation in aplastic anemia.
    • These immunological findings contribute to understanding the complex pathogenesis of aplastic anemia.
    • Further research into T cell subset dynamics may offer insights into aplastic anemia treatment strategies.