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Human brain glucose utilization and cognitive function in relation to age.

R Duara, C Grady, J Haxby

    Annals of Neurology
    |December 1, 1984
    PubMed
    Summary
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    Healthy aging does not significantly alter brain glucose metabolism in men. Resting cerebral metabolic rate for glucose (CMRglc) remained stable across ages 21-83, showing no correlation with cognitive performance.

    Area of Science:

    • Neuroscience
    • Gerontology
    • Medical Imaging

    Background:

    • Aging is associated with cognitive decline, potentially linked to changes in brain metabolism.
    • Previous studies on age-related brain metabolism have yielded mixed results, necessitating further investigation.

    Purpose of the Study:

    • To investigate the relationship between age and brain oxidative metabolism in healthy men.
    • To determine if resting cerebral metabolic rate for glucose (CMRglc) changes with age.
    • To explore correlations between brain metabolism and cognitive function in aging.

    Main Methods:

    • Positron emission tomography (PET) with [18F]2-deoxy-D-glucose was used to measure CMRglc in 40 healthy men (ages 21-83).
    • Measurements were conducted under conditions of reduced visual and auditory stimulation to assess resting metabolism.

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  • Cognitive function was assessed using the Benton Revised Visual Retention Test and the Wechsler Adult Intelligence Scale (WAIS).

    • Main Results:

    • Mean CMRglc did not significantly correlate with age (p > 0.05).
    • Regional CMRglc and Q ratios also showed no age-related decline.
    • Cognitive test scores did not correlate with brain metabolic rates; only WAIS Performance scores showed age decrements.

    Conclusions:

    • Brain oxidative metabolism, measured as CMRglc under resting conditions, is maintained in healthy aging men.
    • Resting brain metabolism does not appear to be a significant factor in age-related cognitive changes in this cohort.
    • Findings suggest preserved brain energy metabolism in healthy aging despite some cognitive performance declines.