Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Direct current influence on bone formation in titanium implants.

F Buch, T Albrektsson, E Herbst

    Biomaterials
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Two-piece Zirconia Implants: An Office based Retrospective Study with up to 7 and mean 3 Year Follow-Up.

    The International journal of oral & maxillofacial implants·2025
    Same author

    Hoffa fractures are associated with concomitant soft tissue injures and a high postoperative complication rate.

    Archives of orthopaedic and trauma surgery·2023
    Same author

    Osteoimmune regulation underlies oral implant osseointegration and its perturbation.

    Frontiers in immunology·2023
    Same author

    Primary stability of single-stage revision reconstruction of the anterior cruciate ligament in case of failure of dynamic intraligamentary stabilization depends on implant position during ACL repair.

    Archives of orthopaedic and trauma surgery·2021
    Same author

    [Anterolateral stabilization using the modified Lemaire technique for ACL deficiency].

    Operative Orthopadie und Traumatologie·2018
    Same author

    Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?

    International journal of oral and maxillofacial surgery·2017
    Same journal

    Remodeling TME via feedback-driven photothermal-ferroptosis-immune cascade.

    Biomaterials·2026
    Same journal

    Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

    Biomaterials·2026
    Same journal

    Mg-integrated octopus-inspired hydrogel dressing enables autonomous adhesion and wound closure for enhanced healing via sequential microenvironment regulation.

    Biomaterials·2026
    Same journal

    Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

    Biomaterials·2026
    Same journal

    Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

    Biomaterials·2026
    Same journal

    An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

    Biomaterials·2026
    See all related articles

    Low-level direct current (DC) stimulation significantly enhanced bone formation in rabbit tibial implants. Doses of 5 and 20 microamperes (µA) promoted osteogenesis, while 50 µA showed no measurable effect.

    Area of Science:

    • Biomaterials Science
    • Orthopedic Research
    • Regenerative Medicine

    Background:

    • Titanium implants are widely used in orthopedic surgery.
    • Bone regeneration is crucial for successful implant integration.
    • Electrical stimulation is being explored to enhance bone healing.

    Purpose of the Study:

    • To investigate the effect of direct current (DC) stimulation on bone formation within titanium implants.
    • To determine the optimal current intensity for promoting osteogenesis.

    Main Methods:

    • A dividable titanium implant was inserted into the tibial metaphyses of adult rabbits.
    • Electrodes were placed proximally and distally to the implant.
    • Animals were divided into groups receiving 5 µA, 20 µA, or 50 µA of DC stimulation for three weeks.

    Related Experiment Videos

  • Bone ingrowth into the implant canals was analyzed using macroradiography and numerical analysis.

    • Main Results:

    • DC stimulation with 5 µA and 20 µA resulted in a statistically significant increase in osteogenesis.
    • A current intensity of 50 µA did not yield a measurable increase in bone formation compared to controls.
    • Enhanced bone formation was observed despite the electrodes being placed at a distance from the implant.

    Conclusions:

    • Low-level DC stimulation (5-20 µA) can effectively promote osteogenesis in tibial implants.
    • The distance of electrodes from the implant does not negate the positive effects of stimulation.
    • This finding supports the potential of electrical stimulation as an adjunctive therapy for orthopedic implant osseointegration.