Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-random chromosomal aberrations associated with multiple myeloma.

J P Lewis, M R MacKenzie

    Hematological Oncology
    |October 1, 1984
    PubMed
    Summary

    Cytogenetic abnormalities in multiple myeloma are not random and reveal unique patterns. Specific chromosomal changes, like rearrangements of chromosomes 1 and 14, are common in this blood cancer.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Understanding pharmaceutical exposure and the potential for effects in marine biota: A survey of bonefish (Albula vulpes) across the Caribbean Basin.

    Chemosphere·2023
    Same author

    Reply to "Marine abundance and its prehistoric past in the Baltic".

    Nature communications·2022
    Same author

    Marine resource abundance drove pre-agricultural population increase in Stone Age Scandinavia.

    Nature communications·2020
    Same author

    Natural variability and effects of cleaning and storage procedures on vertebral chemistry of the blacktip shark Carcharhinus limbatus.

    Journal of fish biology·2017
    Same author

    Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.

    Clinical and translational science·2017
    Same author

    Clopidogrel pharmacogenetics: Beyond candidate genes and genome-wide association studies.

    Clinical pharmacology and therapeutics·2016

    Area of Science:

    • Hematology
    • Oncology
    • Cytogenetics

    Background:

    • Multiple myeloma is a cancer of plasma cells.
    • Cytogenetic abnormalities are common in multiple myeloma.
    • Understanding these abnormalities is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the cytogenetic abnormalities in multiple myeloma.
    • To determine if these abnormalities are random or have specific patterns.
    • To compare myeloma cytogenetics with other hematologic malignancies.

    Main Methods:

    • Cytogenetic analysis of myelomatous tissue from 30 patients.
    • Review and integration of data from 18 previously reported cases.
    • Banding techniques for detailed chromosomal analysis.

    Main Results:

    • One-third of patients showed chromosomal deletions, additions, or rearrangements.
    • Cases with normal cytogenetics likely originated from nonmyelomatous tissue.
    • Analysis of 27 cases revealed non-random, unique cytogenetic patterns in multiple myeloma.
    • Specific aberrations include rearrangements of chromosomes 1 and 14, trisomy for chromosomes 3, 5, 7, 9, and 11, and monosomy for chromosomes 8 and 13.
    • Myeloma cytogenetics differ significantly from chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and acute leukemias.

    Conclusions:

    • Cytogenetic abnormalities in multiple myeloma are non-random and disease-specific.
    • Clonal evolution may occur but late-stage abnormalities resemble early-stage ones.
    • Identified chromosomal aberrations provide a basis for molecular biologic studies in multiple myeloma.

    Related Experiment Videos