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Related Experiment Videos

Wasp sting anaphylaxis.

O D Ratnoff, H L Nossel

    Blood
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Wasp sting anaphylaxis caused severe bleeding problems due to an unknown thrombin inhibitor and reduced clotting factors like factor V. Further research is needed to understand this association.

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    INCREASED VASCULAR PERMEABILITY INDUCED BY HUMAN PLASMIN.

    The Journal of experimental medicine·2009

    Area of Science:

    • Hematology
    • Immunology
    • Toxicology

    Background:

    • Anaphylaxis, a severe allergic reaction, can lead to complex physiological disturbances.
    • Hemostatic abnormalities following insect sting anaphylaxis are not fully understood.

    Observation:

    • A patient experiencing wasp sting anaphylaxis exhibited significant hemostatic defects 14 hours post-sting.
    • Plasma analysis revealed an unidentified agent inhibiting thrombin activity.
    • Reduced titers of multiple clotting factors, notably proaccelerin (factor V) and high molecular weight kininogen, were observed.

    Findings:

    • An unknown plasma inhibitor interfered with thrombin, affecting fibrinogen and synthetic amide hydrolysis.
    • The inhibitor was distinct from known plasma thrombin inhibitors and heparin.

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  • Normal Hageman factor (factor XII) levels suggested contact activation pathways were not primary drivers of these defects.

    • Implications:

    • These findings confirm and expand knowledge of hemostatic dysfunction during anaphylaxis.
    • The study highlights the need for further investigation into the mechanisms linking anaphylaxis and coagulation abnormalities.
    • Understanding this association is crucial for managing severe allergic reactions and their complications.