Related Experiment Videos
PAS-positive lymphatic cells in angioimmunoblastic lymphadenopathy
Klinische Wochenschrift
|March 1, 1978
Summary
The periodic acid-Schiff (PAS) reaction can aid in diagnosing angioimmunoblastic lymphadenopathy (AIL). PAS-positive tumor cells were observed in malignant AIL cases, including plasmoblastic sarcoma.
Area of Science:
- Pathology
- Oncology
- Hematology
Background:
- Angioimmunoblastic lymphadenopathy (AIL) is a complex lymphoid disorder.
- Distinguishing malignant AIL from benign forms can be challenging.
- Cytological features of AIL require further characterization.
Purpose of the Study:
- To evaluate the utility of the periodic acid-Schiff (PAS) reaction in the cytological diagnosis of angioimmunoblastic lymphadenopathy.
- To correlate PAS positivity with the malignancy status of AIL cases.
Main Methods:
- Cytological preparations from 8 cases of angioimmunoblastic lymphadenopathy were analyzed.
- The PAS reaction was applied to assess the presence and intensity of PAS-positive material in cells.
- Cases were classified based on malignancy, including plasmoblastic sarcoma.
Main Results:
- Intensely PAS-positive tumor cells were noted in two cases of plasmoblastic sarcoma, resembling those in acute leukemias and lymphomas.
- Four malignant AIL cases showed varying degrees of PAS positivity (very many to occasional positive cells).
- One malignant case was PAS-negative, and the apparently benign case showed some positive cells.
Conclusions:
- The PAS reaction is a valuable diagnostic aid for angioimmunoblastic lymphadenopathy.
- PAS positivity, particularly intense staining in tumor cells, can support the diagnosis of malignant AIL and plasmoblastic sarcoma.