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Indenolol in hypertension.

R Sega, F Mailland, E Damiani

    Clinical Pharmacology and Therapeutics
    |March 1, 1983
    PubMed
    Summary
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    Indenolol effectively lowers blood pressure and heart rate in hypertensive patients. This study shows a dose-dependent effect on systolic pressure and heart rate, with good tolerability.

    Area of Science:

    • Cardiovascular pharmacology
    • Clinical hypertension research

    Background:

    • Hypertension remains a significant global health concern.
    • Effective and well-tolerated antihypertensive medications are crucial for patient management.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of indenolol in hypertensive patients.
    • To assess the dose-response relationship of indenolol on blood pressure and heart rate.

    Main Methods:

    • Double-blind, randomized, placebo-controlled trial.
    • 14 hypertensive inpatients received placebo, then 30-mg or 60-mg indenolol twice daily for 14 days.
    • Measurement of supine and standing arterial pressure and heart rate.

    Main Results:

    • Indenolol significantly reduced systolic and diastolic arterial pressure and heart rate.

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  • Effects on systolic pressure and heart rate were dose and time-dependent.
  • No significant effect observed with placebo.
  • Indenolol was well tolerated without bradycardia.

    • Conclusions:

    • Indenolol demonstrates antihypertensive and heart rate-lowering effects.
    • The drug is well-tolerated in hypertensive individuals.
    • Indenolol presents a potential therapeutic option for hypertension management.