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Related Experiment Videos

Digitalis poisoning: historical and forensic aspects.

H B Burchell

    Journal of the American College of Cardiology
    |February 1, 1983
    PubMed
    Summary

    Digitalis toxicity has a long history, appearing in ancient texts, literature, and real-life cases of poisoning, fraud, and suicide. Physicians must remain vigilant about digitalis

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Medical History

    Background:

    • Digitalis, a cardiac glycoside, has been used therapeutically for approximately 200 years.
    • Historical records, dating back over 400 years, indicate awareness of digitalis plant's poisonous properties.
    • The drug's toxicity has been a recurring theme in both literature and clinical practice.

    Observation:

    • Documented instances of digitalis use in alleged homicides, suicides, and fraudulent disability claims.
    • Historical pharmaceutical manufacturing blunders involving mislabeled digitalis products led to numerous deaths.
    • Reported cases of psychiatric illness associated with digitalis toxicity.

    Findings:

    • Digitalis toxicity encompasses a wide range of adverse events, from accidental overdose to intentional misuse.
    • Historical misuse includes homicidal intent, suicidal attempts, and elaborate insurance fraud schemes.
    • Pharmaceutical blunders highlight the critical importance of accurate drug manufacturing and labeling.

    Implications:

    • Physicians must maintain vigilance regarding digitalis' potential for poisoning due to improper dosage, pharmacodynamics, or drug interactions.
    • Awareness of digitalis toxicity is crucial for preventing accidental overdoses, especially in pediatric populations.
    • The historical context of digitalis toxicity underscores the ongoing need for careful prescribing and patient monitoring.

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