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Pharmacologic basis for developing rational drug regimens for elderly patients.

P B Goldberg, J Roberts

    The Medical Clinics of North America
    |March 1, 1983
    PubMed
    Summary

    Drug responsiveness and adverse reactions increase with age due to physiological changes and polypharmacy. Understanding these factors is key to developing safer geriatric drug regimens.

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    Area of Science:

    • Geriatric pharmacology
    • Drug metabolism and pharmacokinetics
    • Adverse drug reactions

    Background:

    • Age-related changes affect drug responsiveness across various drug classes.
    • Adverse drug reactions are more prevalent in older adults due to increased drug use and polypharmacy.
    • Diminished organ function in the elderly impacts drug distribution and elimination.

    Purpose of the Study:

    • To review factors contributing to altered drug sensitivity in aging.
    • To highlight the issue of adverse drug reactions in the elderly, exacerbated by polypharmacy.
    • To emphasize the need for rational therapeutic drug regimens for geriatric patients.

    Main Methods:

    • Review of existing literature on age-related drug responsiveness.
    • Focus on factors influencing drug sensitivity and adverse drug reactions.
    • Analysis of drug interactions significant in geriatric therapeutics.

    Main Results:

    • Altered drug responsiveness is a common phenomenon in the aging population.
    • Polypharmacy significantly increases the risk of drug interactions and adverse drug reactions in the elderly.
    • Over-the-counter medications contribute to adverse drug events in older adults.

    Conclusions:

    • A deeper understanding of aging physiology and pharmacology is crucial for optimizing geriatric drug therapy.
    • Addressing polypharmacy and drug interactions is essential for improving patient safety in the elderly.
    • Developing rational prescribing practices tailored to geriatric patients can mitigate risks.

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