Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unilateral obstructive nephropathy in the rabbit. II. Late morphologic changes.

R B Nagle, R E Bulger

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Differences in characteristics of men with localised prostate cancer who demonstrate low, intermediate or high prostate-specific antigen velocity.

    Internal medicine journal·2011
    Same author

    Dose-dependent effects of selenized yeast on total selenium levels in prostatic tissue of men with prostate cancer.

    Nutrition and cancer·2010
    Same author

    Nephrotoxicity and uptake of 1-benzyl quinolinium in precision-cut rabbit renal cortical slices.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Effects of acute and chronic arsenic exposure of human-derived keratinocytes in an In Vitro human skin equivalent system: a novel model of human arsenicism.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Gap junctions occur in vertebrate renal proximal tubule cells.

    The Journal of cell biology·2009
    Same author

    Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer.

    British journal of cancer·2007

    Complete ureteral obstruction in rabbits causes kidney damage, including papillary necrosis and cell injury. Fibroblast proliferation and basement membrane changes occur, contributing to obstructive nephropathy.

    Area of Science:

    • Nephrology
    • Pathology
    • Urology

    Background:

    • Complete unilateral ureteral obstruction is a model for studying obstructive nephropathy.
    • Understanding the late-stage renal effects is crucial for managing urinary tract obstruction.

    Purpose of the Study:

    • To investigate the late histologic and ultrastructural changes in rabbit kidneys following ureteral obstruction.
    • To correlate observed morphologic alterations with known physiological and clinical aspects of obstructive uropathy.

    Main Methods:

    • Histologic and ultrastructural examination of rabbit kidneys at 7, 16, and 32 days post-obstruction.
    • Assessment of papillary necrosis, interstitial space, fibroblast activity, and nephron cell morphology.

    Main Results:

    Related Experiment Videos

    • Papillary necrosis was evident by day 7.
    • Progressive interstitial fibrosis and myofibroblast transformation of fibroblasts were observed.
    • Nephron segments showed sublethal cell injury and dedifferentiation, with new basement membrane formation starting on day 16.

    Conclusions:

    • Late-stage ureteral obstruction induces significant renal structural damage.
    • Observed changes include interstitial fibrosis, myofibroblast differentiation, and tubular cell dedifferentiation.
    • These findings provide insights into the pathogenesis of obstructive nephropathy.