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Zinc and infection.

B Sugarman

    Reviews of Infectious Diseases
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Zinc is essential for life, playing key roles in enzymes and cell membranes. Low zinc levels during infection may reduce microbial virulence and protect the host, but prolonged deficiency impairs immunity.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Microbiology

    Background:

    • Zinc is a vital element for all living organisms, crucial for metalloenzymes and membrane stability in microbes and mammals.
    • Zinc can non-specifically bind to proteins and alter their function, impacting biological processes.
    • Serum zinc levels often decrease during infections, influencing host-pathogen interactions.

    Purpose of the Study:

    • To explore the multifaceted roles of zinc in biological systems.
    • To investigate the impact of varying zinc concentrations on microbial virulence and host immunity.
    • To understand the relationship between zinc status and susceptibility to infections.

    Main Methods:

    • Literature review on zinc's biochemical functions.
    • Analysis of existing data on serum zinc levels during infections.

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  • Examination of studies on zinc's effects on immune cells (T-cells and B-cells) and microbial virulence.

    • Main Results:

    • Zinc is integral to metalloenzymes and membrane stabilization.
    • Decreased serum zinc during infections may reduce microbial virulence and offer host protection.
    • Prolonged zinc deficiency in mammals impairs T-cell function while B-cell function remains largely unaffected.

    Conclusions:

    • Zinc plays a dual role in infection, potentially protective at low levels but detrimental when deficient long-term.
    • Further research is required to fully elucidate zinc's biochemistry and its complex relationship with host susceptibility to infection.