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Canine left ventricular performance during LD50 endotoxemia.

R D Goldfarb, W Tambolini, S M Wiener

    The American Journal of Physiology
    |March 1, 1983
    PubMed
    Summary
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    Survival from endotoxin shock depends on maintaining cardiac contractility. Animals that maintained normal myocardial contractility survived, while those with diminished contractility did not survive endotoxin administration.

    Area of Science:

    • Cardiovascular Physiology
    • Sepsis Pathophysiology
    • Endotoxin Shock Research

    Background:

    • Previous studies on endotoxin shock's cardiac effects yielded inconsistent results.
    • Discrepancies may stem from cardiac performance indices sensitive to heart rate or contraction preconditions.
    • A reliable method to assess cardiac performance independent of these factors is needed.

    Purpose of the Study:

    • To test if cardiac performance diminishes in nonsurviving animals post-endotoxin.
    • To determine if cardiac performance is maintained in surviving animals after endotoxin administration.
    • To evaluate the end-systolic pressure-diameter relationship (sigma ES) as a stable cardiac performance index.

    Main Methods:

    • Administered a median lethal dose (LD50) of E. coli endotoxin to animals.

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  • Utilized end-systolic pressure-diameter relationship (sigma ES) analysis for cardiac performance.
  • Monitored other cardiodynamic measurements, including heart rate and aortic pressure.
  • Compared measurements between surviving and nonsurviving animal groups.

    • Main Results:

    • The sigma ES measurement proved independent of afterload and relatively insensitive to heart rate changes.
    • Nonsurviving animals showed a marked depression in sigma ES after endotoxin.
    • Surviving animals exhibited a transient, nonsignificant decrease in sigma ES, followed by recovery.
    • Other cardiodynamic measurements were confounded by significant changes in heart rate and vascular function.

    Conclusions:

    • Diminished myocardial contractility, indicated by sigma ES depression, predicts nonsurvival within 2.5 hours post-endotoxin.
    • Survival is associated with the ability to maintain normal cardiac contractility.
    • The end-systolic pressure-diameter relationship is a robust indicator of cardiac performance during endotoxin shock.