S100 protein in human chordoma and human and rabbit notochord

S100 protein is a protein that has been considered to be specific for tissues of neuroectodermal origin; however, recent studies have demonstrated the presence of S100 protein in mesodermal tissues. Using immunohistochemical methods, we found S100 protein in human chordomas and in human and rabbit notochordal tissue. Our findings suggest that S100 protein is present not only in neuroectodermal tissue but in mesodermal tissue, which develops in close proximity to neuroectoderm.